The United Nations (UN) is appealing for $20.1 billion to fund aid operations in 2016, with two-fifths needed to help those affected by the war in Syria.
UN aid Chief Stephen O’Brien said suffering in the world had reached levels not seen in a generation, with 87 million people needing urgent help.
An unprecedented number of people have also been driven from their homes.
Alongside Syria, the crises in Iraq, South Sudan and Yemen are expected to remain top humanitarian priorities.
The UN also warned that humanitarian organizations were approaching the end of this year with less than half of the 2015 appeal funded by donors.